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Start and Stop Codons

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The start codon AUG sets an mRNA's reading frame and specifies methionine; three stop codons, UAA, UAG, and UGA, end translation without specifying any amino acid.

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A ribosome begins reading at AUG and continues, codon by codon, until it reaches UAA, UAG, or UGA.

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A stop codon has no matching tRNA — that absence, not a special pairing event, ends translation.