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Biology / Unit 6   Bio 1255 short lesson, about 20 seconds

The Reading Frame

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The idea

The reading frame is the specific grouping of an mRNA sequence into consecutive, non-overlapping codons, fixed by where translation begins.

In practice

The sequence AUGGGCUAA reads as AUG-GGC-UAA in its correct frame, but as a different, meaningless set of codons if shifted by one base.

Where people slip

An mRNA has three possible reading frames, but the start codon fixes which one is actually translated.

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