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Biology / Unit 6   Bio 1293 short lesson, about 20 seconds

Translation Termination

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The idea

Translation termination occurs when a stop codon reaches site A, where a release factor, not a tRNA, binds and frees the protein.

In practice

A release factor recognizes stop codon UAA, UAG, or UGA at site A and triggers hydrolysis, releasing the finished polypeptide.

Where people slip

No tRNA carries an anticodon matching a stop codon — a release factor's shape mimics tRNA closely enough to bind.

Your place on the trail

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