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Biology / Unit 6   Bio 1289 short lesson, about 20 seconds

Translation Initiation

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The idea

Translation initiation assembles the small ribosomal subunit, an initiator tRNA carrying methionine, and the mRNA's start codon, before the large subunit joins.

In practice

In eukaryotes, the small subunit scans the mRNA from its 5' end until the initiator tRNA pairs with the AUG start codon.

Where people slip

Initiation ends once both subunits assemble at the start codon — no amino acid bond has yet formed.

Your place on the trail

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