Tracing DNA from Structure Through Replication and Repair
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State
This capstone traces one DNA molecule from its double-helix structure through semiconservative replication to the repair pathways that keep its sequence accurate.
Watch for
Each safeguard catches a different class of error — proofreading during synthesis, mismatch repair immediately after, excision repair for later external damage — and none of the three substitutes for the other two.
Builds on
- 1201 Watson and Crick's Double-Helix Model (1953)
- 1209 The Double Helix's Overall Structure
- 1211 Meselson and Stahl's Semiconservative-Replication Experiment (1958)
- 1229 Tracing One Replication Fork from Origin to Ligation
- 1239 DNA Polymerase Proofreading
- 1241 Mismatch Repair
- 1243 Nucleotide Excision Repair