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Reproductive Cloning and Somatic Cell Nuclear Transfer

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Reproductive cloning produces a genetically matched organism using somatic cell nuclear transfer: transferring a donor's diploid nucleus into an enucleated egg, a technique also usable therapeutically.

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Dolly the sheep, born in 1996, developed from a donor nucleus transferred into an enucleated egg and implanted in a surrogate.

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Nuclear transfer supplies the donor's nuclear DNA; the egg's cytoplasm still shapes early development.