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Biology / Unit 4   Bio 0877 short lesson, about 20 seconds

Cell-Cycle Checkpoints, Three Gates

Captions available

The idea

A cell-cycle checkpoint is an internal control point halting progress until required conditions are met, with major checkpoints at the end of G1, at the G2-to-mitosis transition, and during metaphase.

In practice

A cell with unrepaired DNA damage can be held indefinitely at one checkpoint rather than proceeding.

Where people slip

These checkpoints are internal gates, distinct from the external growth-factor signals that trigger the cycle.

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