Biology / Unit 4 Bio 0807 worked example, 60 to 90 seconds
The Phosphoinositide Pathway: PIP2 to DAG and IP3
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The idea
The phosphoinositide pathway converts a membrane phospholipid into two second messengers, diacylglycerol and inositol triphosphate, when a G-protein-linked receptor activates the enzyme phospholipase C.
Where people slip
Diacylglycerol and inositol triphosphate come from the same cleavage event but act through separate downstream targets — one at the membrane, one released into the cytoplasm.
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