Signal Transduction Can Drive Cell Growth
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A growth factor is a ligand that binds a receptor tyrosine kinase and, through the RAS G-protein and the MAP kinase pathway, drives a cell toward division.
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The epidermal growth factor receptor triggers a cascade that leads a cell to grow and divide once its ligand binds.
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Cells do not divide spontaneously — division requires an external growth-factor signal reaching this pathway.