Receptor-Mediated Endocytosis
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Receptor-mediated endocytosis uses a specific receptor to bind one substance before the membrane folds inward and brings it into the cell.
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Cells clear LDL cholesterol through receptor-mediated endocytosis; a defective LDL receptor lets cholesterol build to dangerous blood levels.
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A missing or defective receptor blocks this pathway — the substance stays in circulation rather than entering the cell.