Negative Feedback in Hormone Regulation
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Hormone production and release are primarily controlled by negative feedback, per Bio 2749, where a rising level inhibits the signaling that produced it, keeping concentration in a narrow range.
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Rising thyroid hormone feeds back to inhibit the hypothalamus and pituitary, reducing further TSH signaling.
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Negative feedback dominates hormone regulation as it dominates other systems — positive feedback, per Bio 2751, stays rare.