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Three Stimuli Triggering Hormone Release

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Endocrine glands release hormones in response to three stimulus types: humoral, from changing fluid composition; hormonal, from another hormone's signal; and neural, direct from the nerves.

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Rising blood glucose is a humoral stimulus triggering insulin; TSH triggering thyroid hormone release is hormonal.

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A gland can respond to more than one stimulus type — the adrenal medulla responds to neural stimuli, unlike most.