Intracellular Hormone Receptors and Gene Transcription
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A lipid-soluble hormone bound to its intracellular receptor acts as a transcription regulator, increasing or decreasing synthesis of specific mRNA molecules and, in turn, specific proteins.
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A steroid hormone-receptor complex binds a hormone response element on DNA, triggering transcription of a target gene.
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This mechanism changes cell function by altering what proteins get made, not by acting on existing proteins directly.