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Baltimore Groups I–III

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Group I viruses carry double-stranded DNA; Group II carry single-stranded DNA; Group III carry double-stranded RNA, each converted to mRNA differently.

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Herpesviruses are Group I, transcribing mRNA like a host cell; rotavirus is Group III, transcribing mRNA from its double-stranded RNA genome.

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Group II's single-stranded DNA genome must first become double-stranded before transcription— it cannot be transcribed directly in single-stranded form.