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Biology / Unit 7   Bio 1597 short lesson, about 20 seconds

"The Genome Fully Predicts the Proteome"

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The idea

A genome does not fully predict its proteome, because alternative splicing and post-translational modification add diversity the DNA sequence alone does not fix.

In practice

Alternative splicing of one gene's pre-mRNA, per Bio 1331, produces more than one protein from a single sequence.

Where people slip

A genome sets which proteins are possible; splicing and modification, not the genome alone, determine which proteins a cell actually makes.

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