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Proto-oncogenes and Oncogenes

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A proto-oncogene is a normal gene coding for a positive cell-cycle regulator; an oncogene is a mutated version that speeds cell-cycle progression.

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A mutation letting a Cdk activate without its cyclin partner can push a cell past a checkpoint too soon.

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A gene is an oncogene only after mutation changes its function — the unmutated form is routine, healthy regulation.