Smooth Endoplasmic Reticulum
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The smooth ER is continuous with the rough ER but carries few or no ribosomes, and instead synthesizes lipids and steroid hormones, detoxifies chemicals, and stores calcium.
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In 1960s electron-microscopy studies of adrenal cortex cells, researchers linked their calcium-storing smooth ER to steroid hormone synthesis.
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Rough and smooth ER are one continuous system, distinguished by function, not separate organelles.
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