Denaturation
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State
Denaturation is the loss of a protein's folded structure, caused by heat, extreme pH, or conditions that disrupt the bonds holding its shape.
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Heating an egg white denatures its proteins, turning clear, folded proteins into an opaque, tangled solid that cannot refold.
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Denaturation changes a protein's shape, not its sequence — the amino acid chain stays intact even as its structure collapses.
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