Biology / Unit 7 Bio 1577 short lesson, about 20 seconds
Whole-Genome versus Whole-Exome Sequencing
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The idea
Whole-genome sequencing determines an organism's entire DNA sequence, while whole-exome sequencing determines only its protein-coding exon regions.
In practice
Whole-exome sequencing reads the exons a gene's mRNA is built from, per Bio 1275, skipping the introns and non-coding DNA whole-genome sequencing includes.
Where people slip
Whole-exome sequencing covers a smaller genome fraction by design — not a lower-resolution read of the regions whole-genome sequencing covers.
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