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Biology / Unit 6   Bio 1233 short lesson, about 20 seconds

Eukaryotic Replication's Multiple Origins and Polymerases

Captions available

The idea

A eukaryotic chromosome replicates from many origins at once, and uses several distinct DNA polymerases rather than the few found in prokaryotes.

In practice

A single human chromosome opens hundreds of replication bubbles simultaneously, each with its own forks, finishing far faster than one origin could.

Where people slip

Multiple origins solve a length problem, not a fidelity problem — proofreading is what keeps eukaryotic replication accurate.

Your place on the trail

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