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Eukaryotic Replication's Multiple Origins and Polymerases

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A eukaryotic chromosome replicates from many origins at once, and uses several distinct DNA polymerases rather than the few found in prokaryotes.

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A single human chromosome opens hundreds of replication bubbles simultaneously, each with its own forks, finishing far faster than one origin could.

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Multiple origins solve a length problem, not a fidelity problem — proofreading is what keeps eukaryotic replication accurate.