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Epistasis

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Epistasis occurs when one gene masks or alters a second gene's phenotype, producing an F2 ratio departing from the standard 9:3:3:1.

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In mouse coat color, a pigment gene's recessive homozygous genotype blocks all pigment, masking a separate coat-pattern gene — an albino mouse's pattern genotype stays invisible.

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Epistasis is an interaction between two genes' products, not a single gene's dominant-recessive pair.

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