Higher-Order Chromatin Packing
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State
Beyond the nucleosome, DNA coils into a 30-nanometer chromatin fiber, then into loops organized by fibrous proteins, reaching its most condensed state during mitosis.
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Each chromosome occupies its own territory in the nucleus without overlapping neighbors, a spacing these packing levels help maintain.
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Chromatin packing is dynamic — it loosens and tightens with gene needs and cell-cycle stage.