Signaling in Yeast
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Budding yeast cells signal mating partners by secreting mating factor, a ligand binding cell-surface receptors that halts the recipient's growth cycle to prepare for mating.
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A yeast cell receiving mating factor activates protein kinases and GTP-binding proteins resembling multicellular G-protein signaling.
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Single-celled eukaryotes use cell-surface receptor signaling like an animal cell — communication did not begin with multicellularity.
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