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Biology / Unit 4   Bio 0797 short lesson, about 20 seconds

Signal Amplification

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The idea

Signal amplification lets one bound ligand and one activated receptor-linked enzyme activate many copies of the next protein in a cascade, multiplying the original signal.

In practice

A single activated enzyme in a cascade can modify hundreds of downstream target molecules before the signal terminates.

Where people slip

Amplification happens at enzyme-catalyzed steps in the cascade — the initial ligand-receptor binding itself is one-to-one.

Your place on the trail

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