Chemistry / Unit 12 Chem 2475 short lesson, about 20 seconds
Amides Distinguished from Amines by the Carbonyl
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The idea
An amide's nitrogen bonds directly to a carbonyl carbon, unlike an amine's nitrogen, which bonds only to carbon or hydrogen.
In practice
The peptide bond linking amino acids is an amide, formed between one acid's carboxyl and the next's amine group.
Where people slip
Amides are weaker bases than amines since the carbonyl draws density from nitrogen's lone pair — treating amide nitrogen as basic ignores this.
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