Hormonal Control: Gastrin, Secretin, CCK
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Gastrin stimulates stomach acid release; secretin triggers pancreatic bicarbonate to neutralize chyme; cholecystokinin triggers pancreatic enzymes and gallbladder bile release, coordinating digestion across organs.
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Fatty chyme entering the duodenum triggers cholecystokinin release, prompting bile delivery exactly when fat needs emulsifying.
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Somatostatin, not gastrin, is the hormone that stops acid release once the stomach empties — the two work in opposition.